Laboratory Introduction
Dr. Wenhui He received his Bachelor's degree in Bioengineering from Xi'an Jiaotong University and his PHD from National Institute of Biological Sciences, Beijing. He subsequently completed his postdoctoral training from 2013 to 2017 in Dr. Wenhui Li's lab at the National Institute of Biological Sciences, Beijing. Between 2017 and 2022, he worked as a postdoctoral fellow in Dr. Michael Farzan's lab at The Scripps Research Institute. In 2023, he joined Boston Children's Hospital and the Broad Institute, affiliated with Harvard Medical School. He was appointed Assistant Investigator at CIMR in 2024. His team develops novel viral vaccines, antibody-directed oncolytic viruses and membrane-targeted protein therapeutics using an in vivo protein evolution platform based on B cell germinal centers. His academic achievements include establishing a mouse model of hepatitis delta virus infection, participating in the discovery of the hepatitis B virus receptor, developing evaluation models for HIV vaccines and building the in vivo protein evolution platform.
Dr. He's lab employs B-cell based in vivo protein evolution platforms combined with high-throughput functional antibody screening to generate functional antibodies targeting multi-pass transmembrane proteins for pain therapy. The group also works on HIV vaccines and therapeutic protein molecules, and explores novel gene delivery strategies to achieve functional cure of HIV.
Lab Website: https://www.cimrbj.ac.cn/en/channel/1768515110416027648.html
Open Positions:
Postdoctoral Researcher
This postdoctoral position is jointly offered by Dr. He's lab at CIMR and Dr. Xia Meng's lab at Beijing Ditan Hospital, Capital Medical University. Leveraging the abundant clinical resources of Beijing Ditan Hospital and state-of-the-art antibody discovery & immunology platforms at CIMR, the research focuses on developing immunotherapies for atherosclerosis and stroke. The appointed postdoc will conduct research on therapeutic antibodies targeting key multi-pass transmembrane proteins using the lab's unique in vivo protein evolution platform.
Main Responsibilities
a. Design and conduct antibody discovery, atherosclerosis and stroke-related experiments; lead/collaborate on national/provincial research projects.
b. Analyze data, write high-impact manuscripts, patents and project reports.
c. Assist PI with grant proposal preparation.
d. Mentor graduate/undergraduate students, maintain lab platforms and engage in academic collaborations.
Qualifications
a. PhD in Immunology, Cell & Molecular Biology, Virology, Basic Medicine or related fields; candidates with atherosclerosis and animal experiment experience preferred.
b. Proficient in cell culture, gene editing, vector construction, flow cytometry and other core molecular/cell techniques.
c. First-author SCI paper(s) published/accepted; independent scientific thinking, strong problem-solving ability.
d. Team player with good resilience; proficient in English for literature reading, paper writing and academic presentation.
Welfare Treatment
a. Competitive salary based on the applicant’s work experience and ability (salary negotiable).
b. Social insurance and housing fund, supplementary medical insurance, physical examination and paid annual leave.
c. Opportunities for career development and available professional guidance.
Applicants should submit the following materials by email (hewenhui@cimrbj.ac.cn)
· Curriculum vitae (CV);
· A brief description of research interests or a research proposal;
· Names and contact information of 2–3 referees;
· Other relevant materials demonstrating research experience and scientific achievements.
Contact Person: Prof. Wenhui He
Address: 10 Xitoutiao, Youanmen Wai, Fengtai District, Beijing 100069, China – Chinese Institutes for Medical Research, Beijing (CIMR)
This recruitment is valid for the long term until a suitable candidate is recruited.
10 Xitoutiao, Youanmen Wai, Fengtai District, Beijing 100069, China
010-86738999
cimr@cimrbj.ac.cn
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