Dr. Ghosh received his Ph.D. in Molecular Biology from the Albert Einstein College of Medicine in 1988. He carried out his postdoctoral research as an Irvington Institute postdoctoral fellow with Dr. David Baltimore at the Whitehead Institute of MIT in Cambridge, MA. It was there that Dr. Ghosh began his seminal work in understanding the regulation of Nuclear Factor-kappa B (NF-kappa B / NF-kB), a transcription factor that plays a critical role in regulating the expression of a large number of genes involved in the mammalian immune system. Dr. Ghosh's research led to the first cloning of NF-kB and IkB proteins, and their characterization, including the demonstration of the role of IkB phosphorylation in the activation of NF-kB.

Dr. Ghosh began his independent research career at Yale University School of Medicine in 1991, where he was a Professor in the Departments of Immunobiology and Molecular Biophysics & Biochemistry, and an Investigator of the Howard Hughes Medical Institute. At Yale his laboratory made numerous original findings that helped establish the mechanism of transcriptional regulation of NF-kB proteins, identification and characterization of signaling intermediates in innate and adaptive immune system, and identification and characterization of a subset of Toll-like receptors. In 2008 he was recruited to Columbia University to be the chairman of the Department of Microbiology and Immunology.

A biochemist, immunologist and microbiologist, Dr. Ghosh continues to be best known for his work on NF-kB. Because NF-kB plays an important role in regulating the expression of a number of genes involved in inflammation and the immune responses, his research has implications for the treatment of arthritis, colitis, dermatitis, asthma, and other inflammatory diseases, as well as diseases such as cancer and muscular dystrophy. However his research interests have expanded over the years and encompasses the study of long non-coding RNAs and microRNAs in the inflammatory process. His recent work has also illuminated novel mechanisms and pathways by which the NF-kB pathway influences immune responses to cancer.

Homepage: https://www.sankarghoshlab.org/people2