NO. 83
Time:
Monday, Sep. 22 2025, 4:00 p.m.
Location:
Multi-Function Hall, 2nd Floor, North Basic Research Building
Host：
Yuval Rinkevich
Chinese Institutes for Medical Research, Beijing
Speaker：
Ophir Klein, PhD, MD
Professor
Cedars-Sinai, Pediatrics
TITLE：
Development and Renewal in the Mouth and Gut
ABSTRACT:
Dr. Klein’s research focuses on understanding how organs form in the embryo and how they regenerate in the adult, with a particular emphasis on the processes underlying craniofacial and dental development and renewal, as well as understanding how intestinal stem cells and their niche enable GI tract regeneration.
SELECTED PAPERS
1. Zwick RK, Kasparek P, Palikuqi B, Viragova S, Weichselbaum L, McGinnis CS, McKinley KL, Rathnayake A, Vaka D, Nguyen V, Trentesaux C, Reyes E, Gupta AR, Gartner ZJ, Locksley RM, Gardner JM, Itzkovitz S, Boffelli D, Klein OD. Epithelial zonation along the mouse and human small intestine defines five discrete metabolic domains. Nat Cell Biol. 2024 Feb; 26(2): 250-262.
2. Viragova S, Li D, Klein OD. Activation of fetal-like molecular programs during regeneration in the intestine and beyond. Cell Stem Cell. 2024 Jul 5; 31(7): 949-960.
3. Castillo-Azofeifa D, Wald T, Reyes EA, Gallagher A, Schanin J, Vlachos S, Lamarche-Vane N, Bomidi C, Blutt S, Estes MK, Nystul T, Klein OD. A DLG1-ARHGAP31-CDC42 axis is essential for the intestinal stem cell response to fluctuating niche Wnt signaling. Cell Stem Cell. 2023 Feb 2; 30(2): 188-206.e6.
10 Xitoutiao, Youanmen Wai, Fengtai District, Beijing 100069, China
010-86738999
cimr@cimrbj.ac.cn
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