NO. 79
CIMR Wednesday Lecture Series
Time:
Wednesday, Jul. 16 2025, 4:00 p.m.
Location:
Multi-Function Hall, 2nd Floor, North Basic Research Building
Host：
Shao-Cong Sun (孙少聪)
Chinese Institutes for Medical Research, Beijing
Speaker：
Di Yu
Chair Professor
Frazer Institute and Child Health Research Centre
University of Queensland
TITLE：
Tfh Cells: The Architects of Adaptive Immunity
ABSTRACT:
Adaptive immunity is defined by its precision in targeting non-self antigens and its capacity for long-term protection. Follicular helper T (Tfh) cells represent the archetype of CD4+ T cell help, essential for orchestrating B cell activation and antibody production—a role first recognised in the 1960s. However, only in the past two decades have we begun to unravel the complex molecular mechanisms that govern Tfh cell differentiation and function. In this talk, I will highlight how recent discoveries in biochemical and metabolic regulation have deepened our understanding of Tfh cells as central coordinators of both humoral and cellular immunity. These insights open new avenues for optimising vaccination and advancing cancer immunotherapy.
SELECTED PAPERS
1. Yao Y, Chen Z, Zhang H, Chen C, Zeng M, Yunis J, Wei Y, Wan Y, Wang N, Zhou M, Qiu C, Zeng Q, Ong HS, Wang H, Makota FV, Yang Y, Yang Z, Wang N, Deng J, Shen C, Xia Y, Yuan L, Lian Z, Deng Y, Guo C, Huang A, Zhou P, Shi H, Zhang W, Yi H, Li D, Xia M, Fu J, Wu N, de Haan JB, Shen N, Zhang W, Liu Z, Yu D. Selenium-GPX4 axis protects follicular helper T cells from ferroptosis. Nat Immunol. 2021 Sep;22(9):1127-1139.
2. Yu D, Walker LSK, Liu Z, Linterman MA, Li Z. Targeting TFH cells in human diseases and vaccination: rationale and practice. Nat Immunol. 2022 Aug;23(8):1157-1168.
3. Chen Z, Cui Y, Yao Y, Liu B, Yunis J, Gao X, Wang N, Cañete PF, Tuong ZK, Sun H, Wang H, Yang S, Wang R, Leong YA, Simon Davis D, Qin J, Liang K, Deng J, Wang CK, Huang YH, Roco JA, Nettelfield S, Zhu H, Xu H, Yu Z, Craik D, Liu Z, Qi H, Parish C, Yu D. Heparan sulfate regulates IL-21 bioavailability and signal strength that control germinal center B cell selection and differentiation. Sci Immunol. 2023 Feb 24;8(80):eadd1728.
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