IRBM Seminar
Time:
Wednesday, May. 7 2025, 3:00 p.m.
Location:
Multi-Function Hall, 2nd Floor, North Basic Research Building
Host：
Yuval Rinkevich
Chinese Institutes for Medical Research, Beijing
Speaker：
Benjamin Dekel
Professor
Tel Aviv University, Israel
TITLE：
URINE IS GOLD
ABSTRACT:
Chronic kidney disease (CKD) is a worldwide epidemic. I will discuss possible solutions for CKD using principles of regenerative biology and medicine. Our previous efforts spanned from transplantation of embryonic kidney precursor tissues to prospective isolation and characterisation of kidney tissue stem/progenitor and utilisation as cell therapies. We now direct our efforts at growing kidney spheroids and organoids from tissue progenitors for disease modelling and kidney repair with special emphasis on human urine as a source. Our novel solutions carry potential to shape renal medicine.
SELECTED PAPERS
1. Rinkevich Y, Montoro DT, Contreras-Trujillo H, Harari-Steinberg O, Newman AM, Tsai JM, Lim X, Van-Amerongen R, Bowman A, Januszyk M, Pleniceanu O, Nusse R, Longaker MT, Weissman IL, Dekel B. In vivo clonal analysis reveals lineage-restricted progenitor characteristics in mammalian kidney development, maintenance, and regeneration. Cell Rep. 2014 May 22; 7(4): 1270-83.
2. Romagnani P, Rinkevich Y, Dekel B. The use of lineage tracing to study kidney injury and regeneration. Nat Rev Nephrol. 2015 Jul; 11(7): 420-31.
3. Harari-Steinberg O, Metsuyanim S, Omer D, Gnatek Y, Gershon R, Pri-Chen S, Ozdemir DD, Lerenthal Y, Noiman T, Ben-Hur H, Vaknin Z, Schneider DF, Aronow BJ, Goldstein RS, Hohenstein P, Dekel B. Identification of human nephron progenitors capable of generation of kidney structures and functional repair of chronic renal disease. EMBO Mol Med. 2013 Oct; 5(10): 1556-68.
10 Xitoutiao, Youanmen Wai, Fengtai District, Beijing 100069, China
010-86738999
cimr@cimrbj.ac.cn
中文
