NO. 67

CIMR Wednesday Lecture Series

Time:

Wednesday, Apr. 23 2025, 4:00 p.m.

Location:

Multi-Function Hall, 2nd Floor, North Basic Research Building

Host：

Deguang Liang (梁德光)

Chinese Institutes for Medical Research, Beijing

Speaker：

Shuhua Yue (岳蜀华)

Professor

School of Biological Science and Medical Engineering

Beihang University

TITLE：

Lipid Metabolic Profiling via Quantitative Stimulated Raman Scattering Imaging Opens Up New Avenues for Precision Medicine

ABSTRACT:

Lipid droplet (LD) is a dynamic organelle closely associated with cellular functions and energy homeostasis. Dysregulated LD biology underlies an increasing number of human diseases. Commonly used lipid staining and analytical tools are difficult to provide the information regarding LD distribution and composition at the same time. To address this problem, stimulated Raman scattering (SRS) microscopy uses the intrinsic chemical contrast of biomolecules to achieve both direct visualization of LD dynamics and quantitative analysis of LD composition with high molecular selectivity at the subcellular level. Recent developments of Raman tags have further enhanced sensitivity and specificity of SRS imaging without perturbing molecular activity. Taking these advantages, SRS microscopy has offered great promise for deciphering LD metabolism in single live cells. Our work showcases the applications of SRS microscopy as an emerging platform to dissect LD biology in development and progression of human diseases. This talk will focus on the development of SRS imaging technology by our research group and its application in precision medicine.

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