Majors for Enrollment: Neurology Neurobiology Biochemistry and Molecular Biology  B.S. in Biological Science, Tsinghua University, China M.S. in Biology, Tsinghua University, China Ph.D. in Biomedical and Pharmaceutical Sciences, Université catholique de Louvain, Belgium  2024.2-Present Assistant Investigator, Chinese Institutes for Medical Research, Beijing, China 2021.6-Present Professor and Principal Investigator, Xuanwu Hospital, Capital Medical University, China 2015.7-2021.5 Postdoc Scholar, University of California, San Diego, USA  The Chai laboratory at CIMR focuses on the forefront of genetic diagnosis and treatment of neurological disorders.

Majors for Enrollment: Oncology Biochemistry and Molecular Biology  B.S. in Life Science, Central China Normal University, ChinaPh.D. in Microbiology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, China 2024.6-PresentAssistant investigator, Chinese Institutes for Medical Research, Beijing, China2021.9-2024.5Senior Research Scientist, Memorial Sloan Kettering Cancer Center, USA2016.8-2021.8Research Scholar, Memorial Sloan Kettering Cancer Center, USA The Deng laboratory focused on the mechanistic understanding of immune regulation in diseases such as cancer, tissue damage, and neurodegenerative diseases, with a particular focus on macrophage biology in these contexts, to develop mechanism-based intervention approaches to improve disease treatment.

Majors for Enrollment: Biochemistry and Molecular Biology  B.S. in Food Science and Technology, Jiangnan University, ChinaPh.D. in Biotechnology, Peking University & National Institute of Biological Sciences, Beijing, China 2025-PresentAssistant Investigator, Chinese Institutes for Medical Research, Beijing, China2024-2025Associate Research Professor, Westlake University School of Life Sciences, China2016-2023Senior Research Scientist, University of Texas Southwestern Medical Center, USA2012-2016Postdoctoral Fellow, Johns Hopkins University School of Medicine, USA2011-2012Postdoctoral Fellow, National Institute of Biological Sciences, Beijing, China The Pengfei Guo laboratory at CIMR works on uncovering the molecular and genetic mechanisms that regulate tissue growth and organ size control, as well as understanding how dysregulation of these processes contributes to human diseases. By utilizing various model systems and integrating cutting-edge techniques in genetics, cell biology, and bioinformatic, we aim to elucidate fundamental biological principles and identify novel pathways involved in disease pathogenesis. Ultimately, our goal is to leverage these discoveries to develop innovative diagnostic tools and effective treatment strategies for diseases, including cancer and developmental disorders.

Majors for Enrollment: Immunology Pathogenic Biology Biochemistry and Molecular Biology  B.S. in Bioengineering, Xi’an Jiaotong University, ChinaPh.D. in Molecular Biology and Biochemistry, National Institute of Biological Science, Beijing, China 2024-PresentAssistant Investigator, Chinese Institutes for Medical Research, Beijing, China2023-2024Senior Staff Scientist, Harvard Medical School affiliated Boston Children's Hospital and the Broad Institute, USA2017-2022Postdoctoral Associate, Scripps Research Institute, USA2013-2017Postdoctoral Associate, National Institute of Biological Science, Beijing, China The He laboratory at CIMR will fully utilize and continuously optimize the protein in vivo evolution platform based on the B cell germinal center to develop a series of best-in-class or first-in-class protein biologics, as well as their derived therapeutic products such as liposome nanoparticles and oncolytic viruses.

Majors for Enrollment: Immunology Pathogenic Biology Biochemistry and Molecular Biology  B.S. in Pharmaceutical Sciences, Peking University, ChinaM.S. in Pharmacology, Peking University, ChinaPh.D. in Pharmacology and Molecular Sciences, Johns Hopkins University, USA 2025.2-PresentAssistant Investigator, Chinese Institutes for Medical Research, Beijing, China2022.2-2025.2Postdoctoral Fellow, Harvard Medical School and Brigham and Women’s Hospital, USA The Jiang laboratory at CIMR is dedicated to using chemical biology approaches to decode the functions of protein post-translational modifications (PTMs) in cancer and other diseases, with a focus on advancing innovative therapeutic strategies.

Majors for Enrollment: Immunology Oncology Biochemistry and Molecular Biology  Professor Chuanyuan Li received his bachelor’s degree from the University of Science and Technology of China, his Ph.D. in Cancer Biology from Harvard University, and his postdoctoral studies at Harvard. He worked as an Assistant Professor, Associate Professor, and Full Professor at Duke University School of Medicine in the United States beginning in 1997. He served as a lifelong professor in Cancer Biology, Pharmacology, and Dermatology and was the Deputy Director of Research in the Dermatology Department.Now Professor Li is Distinguished Investigator and Director of Chinese Institute for Molecular and Cellular Therapeutics, Chinese Institutes for Medical Research, Beijing. Over the years, he has been involved in research on the mechanisms of tumor development, resistance mechanisms of tumors to radiation and chemotherapy, and the discovery of new molecular targets to enhance tumor immunotherapy. In these fields, he has achieved numerous innovative and impactful research results. He has over 150 peer-reviewed scholarly articles, many of which have appeared in prestigious journals such as Nature, Nature Medicine, Cell Stem Cell, and Molecular Cell, among others. Two innovative achievements in tumor immunotherapy from his research have entered the clinical trial phase.

Majors for Enrollment: Biochemistry and Molecular Biology NeurobiologyOncology Immunology Cell Biology Dr. Guomin Li received his bachelor’s and PhD degrees from Wuhan University’s Department of Biology and Wayne State University’s Department of Chemistry, respectively. He worked as a postdoctoral Investigator in the laboratory of Dr. Paul Modrich, the 2015 Nobel Laureate in Chemistry, at Duke University, where he made substantial contributions to the award-winning work. Professor Li was an Endowed Professor at the University of Texas Southwestern Medical Center and the director of the Reece A. Overcash, Jr. Center for Research on Colon Cancer before he was appointed a Distinguished Investigator and Director of Chinese Institute for Cancer Research, Chinese Institutes for Medical Research, Beijing. Professor Li’s laboratory is dedicated to studying DNA mismatch repair (MMR), a critical cellular mechanism ensuring the accuracy of DNA replication. His work contributes to understanding MMR and its role in cancer susceptibility and treatment. He discovered that MMR defects form the molecular basis for various hereditary and sporadic cancers. Professor Li purified and identified most components required for human MMR and reconstructed human MMR reactions in vitro. His lab found that epigenetic factors, including histone modifications and mutations, are crucial components and regulators of MMR. Recently, his laboratory elucidated how MMR-deficient tumors activate the cGAS-STING pathway to promote tumor immune checkpoint therapy.

Majors for Enrollment: Physiology Neurobiology  B.S. in Life Science, Northwest Normal University, ChinaPh.D. in Neurobiology, Institute of Neuroscience, Chinese Academy of Sciences, China 2025.1-PresentAssistant Investigator, Chinese Institutes for Medical Research, Beijing, China2023.12-2024.12Associate Specialist, Howard Hughes Medical Institute & University of California at San Francisco, USA2018.7-2023.7Postdoctoral Researcher, Howard Hughes Medical Institute & University of California at San Francisco, USA2017.8-2018.6Assistant Research Scientist, Institute of Neuroscience, Chinese Academy of Sciences, China The Li laboratory at CIMR works on the mechanisms and functions of organellar physiology and homeostasis, aiming to reveal their implications in pathogenesis of human diseases, such as neurodegeneration, tissue damage and metabolic disorders.

Majors for Enrollment: Biochemistry and Molecular Biology  Dr. Deguang Liang received his bachelor’s degree in Pharmaceutical Sciences from Sun Yat-sen University, and his Ph.D. in Microbiology from Institut Pasteur of Shanghai, Chinese Academy of Sciences. He conducted his postdoctoral research with Dr. Xuejun Jiang at Memorial Sloan Kettering Cancer Center. He will join CIMR as assistant investigator in 2024. His previous studies have been published in prestigious journals such as Cell, Molecular Cell, and Cell Research, among others. Dr. Liang’s lab is dedicated to studying the molecular regulation and biological function of phospholipid (PL) metabolism pathways (e.g., PL de novo synthesis, remodeling, transport, etc.) under different physiological and pathological conditions. PLs are major components of cell membranes, and the dynamic changes in PL composition, on the one hand, regulate the physicochemical properties of cell membranes and influence cellular functions (such as cell migration, phagocytosis, exocytosis, autophagy, mitochondrial aerobic respiration, etc.). On the other hand, they also modulate the sensitivity of cells to ferroptosis (an emerging form of regulated cell death caused by iron-mediated PL peroxidation) and affect the occurrence and progression of related diseases (such as tumors, neurodegenerative diseases, ischemia-reperfusion injury, etc.). Therefore, investigating the intricate feedback regulation of cellular PL metabolism pathways holds significant importance for both basic and translational research.

Majors for Enrollment: Epidemiology and Health Statistics Biochemistry and Molecular Biology B.S., Department of Mathematics, University of Science and Technology of ChinaPh.D., Department of Biostatistics, University of North Carolina at Chapel Hill, USA 2024.6-PresentAssociate Investigator, Chinese Institutes for Medical Research, Beijing, China2024.6-PresentProfessor, Beijing Institute for Brain Disorders, Beijing, China2024.6-PresentProfessor, Capital Medical University, China2021.9-2024.5Associate Professor, School of Statistics, University of Minnesota at Twin Cities, USA2015.8-2021.8Assistant Professor, School of Statistics, University of Minnesota at Twin Cities, USA2013.7-2015.7Postdoctoral Fellow, Harvard University, USA The Liu laboratory at CIMR works on statistical methodology development including causal inference, missing data, sufficient dimension reduction, statistical applications including the design and analysis of Phase I--III clinical trials, and various observational studies.