医学创新论坛第71期

CIMR Wednesday Lecture Series

时间：2025年5月21日（周三）下午16:00

地点：首都医科大学基础科研楼北楼一层逸夫报告厅

主持人：

史凯斌

首都医学科学创新中心

报告人：

戈鹉平

北京脑科学与类脑研究所

高级研究员

报告题目：

Metabolic Consumption and Production by Human Brain and Brain Tumors

摘要：

Metabolism is vital for brain function. However, a systematic investigation to understand the metabolic exchange between the human brain and circulatory system has been lacking. We compared metabolomes and lipidomes of blood samples from cerebral venous sinus and femoral artery to profile the brain’s uptake and release of metabolites and lipids (1,365 metabolites and 140 lipids). We observed a high net uptake of glucose, taurine, and hypoxanthine and identified glutamine and pyruvate as significantly released metabolites by the brain. Triacylglycerols is the most prominent class of lipid consumed by the brain. Our data also showed age-related alterations in the uptake and release of metabolites. We will also talk about some results about the metabolic exchange between brain tumors and circulatory system.

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