再生生物学与医学研究所学术讲座
时间：2025年5月7日（周三）下午15:00
地点：首都医科大学基础科研楼北楼二层多功能厅
主持人：
Yuval Rinkevich
首都医学科学创新中心
报告人：
Benjamin Dekel
Professor
Tel Aviv University, Israel
报告题目：
URINE IS GOLD
摘要：
Chronic kidney disease (CKD) is a worldwide epidemic. I will discuss possible solutions for CKD using principles of regenerative biology and medicine. Our previous efforts spanned from transplantation of embryonic kidney precursor tissues to prospective isolation and characterisation of kidney tissue stem/progenitor and utilisation as cell therapies. We now direct our efforts at growing kidney spheroids and organoids from tissue progenitors for disease modelling and kidney repair with special emphasis on human urine as a source. Our novel solutions carry potential to shape renal medicine.
代表性论文：
1. Rinkevich Y, Montoro DT, Contreras-Trujillo H, Harari-Steinberg O, Newman AM, Tsai JM, Lim X, Van-Amerongen R, Bowman A, Januszyk M, Pleniceanu O, Nusse R, Longaker MT, Weissman IL, Dekel B. In vivo clonal analysis reveals lineage-restricted progenitor characteristics in mammalian kidney development, maintenance, and regeneration. Cell Rep. 2014 May 22; 7(4): 1270-83.
2. Romagnani P, Rinkevich Y, Dekel B. The use of lineage tracing to study kidney injury and regeneration. Nat Rev Nephrol. 2015 Jul; 11(7): 420-31.
3. Harari-Steinberg O, Metsuyanim S, Omer D, Gnatek Y, Gershon R, Pri-Chen S, Ozdemir DD, Lerenthal Y, Noiman T, Ben-Hur H, Vaknin Z, Schneider DF, Aronow BJ, Goldstein RS, Hohenstein P, Dekel B. Identification of human nephron progenitors capable of generation of kidney structures and functional repair of chronic renal disease. EMBO Mol Med. 2013 Oct; 5(10): 1556-68.
北京市丰台区右安门外西头条10号
010-86738999
cimr@cimrbj.ac.cn
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