Laboratory Introduction
Dr. Zhiqiang Yan is a professor and dean of the School of Basic Medical Sciences at Capital Medical University, as well as an investigator and director at Chinese Institute for Medical Physiology, Chinese Institutes for Medical Research, Beijing. He earned his bachelor's degree from Fudan University in 2004 and completed his Ph.D. in neurobiology at the Institute of Neuroscience, Chinese Academy of Sciences, the National Institute of Biological Sciences, Beijing, and the Institute of Biophysics, Chinese Academy of Sciences, from 2004 to 2009. Following his Ph.D., Dr. Yan conducted his postdoctoral research under the mentorship of Academicians Yuh-Nung Jan and Lily Jan at the Howard Hughes Medical Institute and the University of California, San Francisco. In 2013, he became a professor at the School of Life Sciences, Fudan University. From 2020 to 2024, he served as a senior principal investigator and deputy director at the Institute of Molecular Physiology, Shenzhen Bay Laboratory. He has published numerous papers as a corresponding author in high-impact journals, including Neuron, PNAS, Nature Structural & Molecular Biology, Nature Communications, and Cell Reports.
The Yan laboratory studies sensory neurobiology, focuses on identifying the receptors and neural circuits for sensation and interoception, studies their working mechanism and related the diseases in sensory system.
Representative Corresponding Author Publications:
1. W. Zou#, S. Deng#, X. Chen#, J. Ruan#, H. Wang, W. Zhan, J. Wang, Z. Liu, Z. Yan*. TMEM63B functions as a mammalian hyperosmolar sensor for thirst. Neuron, 2025, 113(9): 1430-1445.e5.
2. S. Fu#, X. Pan#, M. Lu#, J. Dong, Z. Yan*. Human TMC1 and TMC2 are mechanically gated ion channels. Neuron, 2025, 113(3): 411–425.e4.
3. S. Li, B. Li, L. Gao, J. Wang, Z. Yan*. Humidity response in Drosophila olfactory sensory neurons requires the mechanosensitive channel TMEM63. Nature Communications, 2022, 13(1): 3814.
4. B. Li#, S. Li#, H. Zheng, Z. Yan*. Nanchung and Inactive define pore properties of the native auditory transduction channel in Drosophila. Proc Natl Acad Sci USA, 2021, 118 (49): e2106459118.
5. Y. Jia#, Y. Zhao#, T. Kusakizako#, Y. Wang, C. Pan, Y. Zhang, O. Nureki*, M. Hattori*, Z. Yan*. TMC1 and TMC2 proteins are pore-forming subunits of mechanosensitive ion channels. Neuron, 2020, 105: 310-321.
Open position
Postdoctoral Researcher
Main Responsibilities
Carry out scientific research under the guidance of the leader of the research group. Conduct scientific research primarily focused on the physiological functions of the TMC and TMEM63 protein families, in which our research group has extensive accumulated experience. The study aims to deeply explore their roles in various physiological processes, including the sensory systems of pain, touch, and proprioception, as well as in digestion, immunity, reproduction, respiration, development, and blood pressure regulation.
Qualifications
a. Ph.D. or recently obtained a Ph.D. degree in biology, basic medicine, or related fields.
b. First-author publication in a peer-reviewed journal (or accepted for publication).
c. Ability to conduct independent research, strong passion for science, rigorous attitude, and teamwork spirit.
Welfare Treatment
a. Competitive salary based on the applicant’s work experience and ability (salary negotiable).
b. Social insurance and housing fund, supplementary medical insurance, physical examination and paid annual leave.
c. Opportunities for career development and available professional guidance.
How to apply
To apply, please send personal resume, research interest or plan, and other materials demonstrating research capabilities to zqyan@cimrbj.ac.cn, with a copy to yan_lab@cimrbj.ac.cn, and indicate the applicant's name and specific job position in the email subject.
Contact Person: Dr. Yan
Contact address: No.10 Xitoutiao, Youanmenwai, Fengtai District, Beijing
This recruitment is valid for the long term until a suitable candidate is recruited
10 Xitoutiao, Youanmen Wai, Fengtai District, Beijing 100069, China
010-86738999
cimr@cimrbj.ac.cn
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