ABOUT IGM
The Institute for Genetics and Molecular Medicine (IGM) is dedicated to advancing research on congenital genetic diseases, cancer, metabolic disorders, and immune-related diseases. We focus on integrating genetic research with the development of diagnostic and therapeutic technologies, aiming to translate disease research into clinical applications. Leveraging the abundant clinical resources of affiliated hospitals of Capital Medical University, IGM supports translational research that bridges bench to bedside. We encourage close collaboration between laboratories and clinical departments to identify disease-causing genes from clinical samples, conduct mechanistic studies and therapeutic development in the lab, and rapidly validate and optimize diagnostic and treatment approaches in patient populations.
Laboratory Introduction
Liming Wang is Investigator and Director of Institute for Genetics and Molecular Medicine, Chinese Institutes for Medical Research, Beijing, and doctoral supervisor.
The laboratory has long focused on researching the neurobiological regulatory mechanisms of body metabolism. It has published numerous research papers in renowned journals such as Nature, Nature Neuroscience, PNAS, eLife, and Cell Research. Meanwhile, it is committed to public science communication and education, publishing popular science books including The Biology Cultivation of Foodies, God's Scalpel, What Is Life, Laughing to the End, and Virus Science for the Busy, with a circulation of over 300,000 copies. The laboratory has successively won awards such as the "Wenjin Book Award" from the National Library of China, the National Excellent Popular Science Works Award from the Ministry of Science and Technology, and the "Wu Dayou Popular Science Writing Award".
Lab website: https://www.cimrbj.ac.cn/en/channel/1849692136124059648.html
Laboratory Research Directions
The survival and health of animals, including humans, largely depend on the precise regulation and maintenance of energy and essential nutrient levels in the body, and the central nervous system (CNS) plays an indispensable role in this regard. By real-time sensing of energy and nutrient reserves within the body, as well as the distribution of food in the environment, the CNS ensures metabolic balance in animals through sophisticated behavioral regulation. Once this regulatory mechanism is disrupted, it may trigger a series of neural and metabolic diseases, including eating disorders and obesity.
Our laboratory has broad interests in biological questions related to the interaction between the nervous system and metabolic system. Our recent research will primarily use techniques such as quantitative behavioral analysis, in vivo calcium imaging, genetic screening and analysis, single-cell transcriptomics, and circuit tracing in Drosophila and mouse models to investigate the following two independent but interrelated biological questions:
· How does the nervous system participate in the regulation of energy and essential nutrient metabolism in the body?
· How do various organs in animals collaborate in the regulation of body metabolism and the occurrence of metabolic diseases?
Open position
Research Assistant
Main Responsibilities:
a. Assist in or independently conduct research projects.
b. Participate in laboratory management and provide administrative support.
Qualifications:
a. Master’s degree or higher in cell biology, neurobiology, or related fields; bachelor’s degree holders with relevant experimental experience will also be considered on a priority basis.
b. Strong resilience, passion for research, and commitment to a scientific career.
c. High ethical standards, excellent hands-on skills, diligence, and teamwork abilities.
d. Priority given to candidates with CET-6 certificate or equivalent proof of English proficiency, or those planning to pursue graduate studies.
Research Directions:
a. Engage in cell-related experiments, including cell culture management, plasmid transfection, stable cell line construction, cell staining, imaging, KO library screening, and metabolite screening.
b. Perform neurocircuitry-related experiments, such as stereotaxic brain injections, fiber photometry, optogenetics/chemogenetics, two-photon in vivo imaging, and tissue clearing imaging.
c. Engage in Drosophila neurocircuitry research, including behavioral assays, in vivo/ex vivo calcium imaging, fluorescent brain slice imaging, optogenetics, and fly stock management.
Welfare Treatment
a. Competitive salary based on the applicant’s work experience and ability (salary negotiable).
b. Social insurance and housing fund, supplementary medical insurance, physical examination and paid annual leave.
c. Opportunities for career development and available professional guidance.
d. Ample opportunities for further academic promotion for outstanding candidates.
How to apply
Interested applicants should compile the following materials in order and send them to igm@cimrbj.ac.cn, naming each file as "Name + Document Title" and using the email subject line "Applicant Name + Position Applied For":
a. CV and a detailed statement of research interests and future plans.
b. List of academic achievements/awards .
c. Names and contact details of two referees (for postdoctoral applicants only).
d. Additional supporting materials (e.g., representative research papers, project reports) to demonstrate research capabilities.
Contact Person: Ms. Ren
Email: igm@cimrbj.ac.cn
Address: No.10 Xitoutiao, Youanmenwai, Fengtai District, Beijing
This recruitment will remain open until suitable candidates are selected.
Candidates are encouraged to apply as early as possible.
10 Xitoutiao, Youanmen Wai, Fengtai District, Beijing 100069, China
010-86738999
cimr@cimrbj.ac.cn
中文
