NO. 74

CIMR Wednesday Lecture Series

Time:

Wednesday, Jun. 11 2025, 4:00 p.m.

Location:

Yifu Lecture Hall, North Basic Research Building 

Host：

Guoliang Chai (柴国梁)

Chinese Institutes for Medical Research, Beijing

Speaker：

Song-Hai Shi (时松海) 

Professor

School of Life Sciences

Tsinghua University

TITLE：

Assembly and operation of the neocortex

ABSTRACT:

The ability of the neocortex to command higher-order brain functions depends on the assembly and operation of intricate neural circuitries comprised of a vast number of diverse neurons and glia. Notwithstanding the progress made in our understanding of the initial specification and the general histology and information flow of the neocortex, the principles and mechanisms that instruct the assembly and operation of neocortical circuits remain largely elusive. The research in my laboratory has focused on searching for the common developmental commodities of neocortical circuits at both the structural and functional levels and linking them with animal behaviors under normal and disease conditions. We have analyzed the molecular and cellular mechanisms that control the production and positioning of neocortical excitatory and inhibitory neurons, as well as glia, with the premise that the origin and lineage relationship guide the formation of defined neuronal ensembles or substrates for effective functional circuit assembly. In this presentation, I will discuss our recent findings and ongoing efforts.

SELECTED PAPERS