NO. 69

Time:

Thursday, May. 8 2025, 4:00 p.m.

Location:

Multi-Function Hall, 2nd Floor, North Basic Research Building

Host：

Zhiqiang Yan (闫致强)

Chinese Institutes for Medical Research, Beijing

Speaker：

Boris Martinac

Professor

Victor Chang Cardiac Research Institute, Australia

Fellow, Australian Academy of Science

TITLE：

Role of the Piezo1 and TRP channel interactome in cellular mechanotransduction

ABSTRACT:

TRP ion channels have been reported to serve as mechanoreceptors in cell mechanotransduction. However, in many instances it is unclear whether TRP channels are the primary transducers of mechanical force in these processes. The results of a recent study demonstrated that mammalian TRP channels were insensitive to tension caused by stretching cell membrane and prompted the idea of Piezo1-TRP channel interactome suggesting that Piezo1 and TRP channels act jointly at the origin of cellular signaling processes. The example of Piezo1 and TRPM4 interaction in cardiomyocytes illustrates how the two channels act in tandem to activate a Ca2+-calmodulin kinase II (CaMKII)-dependent hypertrophic signaling pathway leading to cardiac left ventricular hypertrophy upon pressure overload. This result suggests that TRP channels may act as amplifiers of cellular mechanosensory signaling cascades.

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