医学创新论坛第74期

CIMR Wednesday Lecture Series

时间：2025年6月11日（周三）下午16:00

地点：首都医科大学基础科研楼北楼一层逸夫报告厅

主持人：

柴国梁

首都医学科学创新中心

报告人：

时松海

清华大学生命科学学院

教授

报告题目：

Assembly and operation of the neocortex

摘要：

The ability of the neocortex to command higher-order brain functions depends on the assembly and operation of intricate neural circuitries comprised of a vast number of diverse neurons and glia. Notwithstanding the progress made in our understanding of the initial specification and the general histology and information flow of the neocortex, the principles and mechanisms that instruct the assembly and operation of neocortical circuits remain largely elusive. The research in my laboratory has focused on searching for the common developmental commodities of neocortical circuits at both the structural and functional levels and linking them with animal behaviors under normal and disease conditions. We have analyzed the molecular and cellular mechanisms that control the production and positioning of neocortical excitatory and inhibitory neurons, as well as glia, with the premise that the origin and lineage relationship guide the formation of defined neuronal ensembles or substrates for effective functional circuit assembly. In this presentation, I will discuss our recent findings and ongoing efforts.

代表性论文：